Armodafinil VS Modafinil, Adrafinil, Nuvigil and Other Drugs

Armodafinil VS Modafinil, Adrafinil, Nuvigil and Other Drugs

Artvigil also treats individuals with sleep disorders, and like Armodafinil, it is of a higher potency so you only have to take 150 mg of the drug, as compared to the 200 mg of Modafinil. The benefits of Artvigil are identical to that of Armodafinil.

Armodafinil VS Modafinil, Adrafinil, Nuvigil and Other Drugs

Armodafinil comparison chart: VS Modafinil, Adrafinil, Nuvigil and other drugs. What are the differences, similarities and benefits?

Armodafinil’s classification is as a nootropic drug, and it is used to increase wakefulness and alertness, resulting in an overall enhancement in mental performance. 

Armodafinil is currently being sold as a prescription drug under the brand names Waklert and Nuvigil.

It has had approval by the United States’ Food And Drug Administration (FDA) since 2007.  FDA approval confirms that the brands are safe, legal and completely effective in treating a wealth of sleeping disorders, as well as other positive benefits such as an increase in cognitive skills.

Before considering taking Armodafinil, please consult your doctor or health care physician to see if Armodafinil is right for you. Prior to use be sure to reread the prescribing information and check it with the doctor’s instructions. Armodafinil has some rare health risks and side effects that could affect you, so please see the details below.

What Is Armodafinil?

Armodafinil is a powerful wakefulness enhancer that is used primarily in treating patients who suffer from irregular sleeping patterns or any number of sleeping disorders, most notably:

  • sleep apnea;
  • narcolepsy;
  • shift work disorder.

It is also used to treat individuals who suffer from excessive daytime fatigue or those who need an increase in alertness during a work shift.

Armodafinil VS Modafinil, Adrafinil, Nuvigil and Other DrugsSide Effects of Armodafinil

Armodafinil has little to no side effects in the average user, but side effects have been known to occur in some users, such as dizziness, headache, nausea, or trouble sleeping. For a more comprehensive list of known possible side effects, see the list below:

  • Side Effects of Armodafinilsleep disorders, difficulties with entering into certain phases of sleep;
  • absent-mindedness, inability to concentrate;
  • independent rocking of the limbs, impossible to control or minimize;
  • burning sensation, a strong tingling and numbness in the extremities, which can not be controlled;
  • vomiting;
  • heartburn;
  • stomach pain;
  • constipation;
  • diarrhea;
  • loss of appetite;
  • thirst;
  • dry mouth;
  • sweating;
  • frequent urination.

Armodafinil is known to also have more severe side effects, although instances of these are rare. If you notice symptoms of one or more diseases from the list, stop taking Armodafinil and immediately contact the doctor:

  • rash;
  • blisters;
  • peeling skin;
  • mouth sores;
  • hives;
  • itching;
  • swelling of the eyes, face, lips, tongue, throat, hands, arms, feet, ankles, or lower legs;
  • hoarseness;
  • difficulty breathing or swallowing;
  • weakness;
  • chest pain;
  • pounding or irregular heartbeat;
  • frenzied, abnormally excited mood;
  • hallucinating (both seeing things or hearing voices that do not exist);
  • anxiety;
  • depression;
  • inflicting harm or death on yourself.

XanaxMore side effects may occur than what is listed, so contact your health care provider or your doctor for a complete list of potential side effects.

If you plan on taking Xanax to treat anxiety while on Armodafinil, consult a doctor or health care physician to see if they are compatible.

If you plan on taking Tramadol to treat any pain, whether moderate or severe, consult a doctor or health care physician while on Armodafinil to see if they are compatible.

Armodafinil VS Modafinil

Armodafinil is a derivative of Modafinilwith similar properties, but Armodafinil comes at a much higher potency rate, so you only need to take less of it to achieve similar results. The main factor in comparing the two is potency. Some users prefer the lower potency rate, while others prefer it higher.

Modafinil is of a lower potency and does not require a prescription, so it can be obtained over the counter (OTC). It fights sleeping disorders like narcolepsy and obstructive sleep apnea and helps normalize sleeping patterns while boosting wakefulness during the day without the feeling of constant fatigue. Modafinil can dramatically improve your focus and helps users become more productive in their day to day routine.

Increased fluidity of thought is also one of the benefits of taking Modafinil, and ordinary routines like reading and writing on average use less effort. Higher rates of retention, memory recall, and mental connections have been proven higher when taking the drug.

Additional benefits of Modafinil include improved sensory perceptions and appetite suppression for fat burning and weight loss.

Armodafinil also normalizes and stabilizes your sleeping patterns. You will not experience any drop off of in its effectiveness, and your sleep cycle will not be affected. You’ll still be able to wake up at your normal time. Unlike Modafinil, which disrupts sleeping patterns and keeps you awake 5-10 hours after ingesting, Armodafinil allows you to keep your sleep cycle intact, and provide the wakefulness needed to survive the day.

Nuvigil VS Provigil Comparison

NarcolepsyArmodafinil (commonly known as Nuvigil) and Modafinil (commonly known as Provigilare both classified as non-amphetamine drugs with the same purpose of treating sleeping disorders and keeping users who suffer from chronic fatigue to stay active. Initially Modafinil was solely used to treat narcolepsy, but soon became used for enhancing performance in individuals. This led to the restructuring of the drug to become Armodafinil (also known as Waklert), and as a result contained higher concentrations of plasma to be maintained in the body throughout the day. Here is an overview of the two drugs:

NuvigilProvigil
Drug typeEugeroicEugeroic
Approved usesNarcolepsy, obstructive sleep apnea, shift work sleep disorderNarcolepsy, obstructive sleep apnea, shift work sleep disorder
IngredientsArmodafinilModafinil
FormatsTabletTablet
Dosages50 mg/150 mg/200 mg/250 mg100 mg/200 mg
ManufacturerCephalon Inc.Cephalon Inc.
Legal StatusSchedule IV (US)Schedule IV (US)
Mechanism of actionFunctions by inhibiting reuptake of dopamine and is thought to act as an indirect D2 receptor partial agonist.  It is believed to also elevate histamine levels in the hypothalamus and increase concentrations of other neurotransmitters such as norepinephrine and serotonin. It may activate orexin peptides via stimulation of orexin receptors (OX1 and OX2). It may also increase glutamatergic concentrations / decrease GABAergic activation – and increase electronic coupling.Functions by inhibiting reuptake of dopamine and elevating histamine levels in the hypothalamus.  It also increases levels of other monoamines such as norepinephrine / serotonin / and activation of orexin peptides. Specifically it may stimulate orexin receptors (OX1 and OX2) to promote wakefulness.  The drug may also activate glutamatergic circuits / inhibit GABA neurotransmission / and enhance electronic coupling.
Generic version?NoYes
Half life15 hours12 hours
Common side effectsDizziness, headache, insomnia, nausea, nervousnessDizziness, headache, insomnia, nausea, nervousness
Date approvedJune (2007)(1998)
Effect duration8 hours6 to 8 hours
Investigational usesADHD. Cognitive enhancement. Chronic fatigue syndrome. Depression. Drug addiction. Jet lag. Negative symptoms of schizophrenia.ADHD. Cognitive enhancement. Chronic fatigue syndrome. Delayed sleep phase syndrome. Depersonalization. Depression. Drug addiction. Fibromyalgia. Jet lag. Multiple sclerosis. Parkinson’s disease. Weight loss.

Differences in Mechanisms and Actions

ModafinilThe two drugs are very similar, but there are significant differences in the mechanisms of action. The effect of the drug is regulated by the presence and dosage of the active and auxiliary components.

The principle of operation Armodafinil is based on the inhibition of reuptake of dopamine. The substance affects the concentration of neurotransmitters in the hypothalamus. The level of histamine, serotonin and noradrenaline increase to the highest possible value. It also activates orexin peptides by stimulating orexin receptors. Also, the substance stimulates orexin receptors through orexin peptides.

Modafinil acts on a different principle. The drug slows the reabsorption of dopamine and the histamine level in the hypothalamus, on the contrary, increases. Composite levels of norepinephrine and serotonin are also undergoing change. The concentration of neurotransmitter is gradually increasing, that helps to activate the orexin peptides.

The mechanism of action is not the only difference between drugs. Modafinil belongs to the group of generic medications and is available in the dosage of 100 mg and 200 mg. Armodafinil comes to the market in such dosages of 50 mg, 150 mg, 200 mg, 250 mg. The half-life of Modafinil is 12 hours, and the rate of Armodafinil increased to 15 hours.

The duration of effect after administration of Armodafinil is 8 hours. Modafinil can operate from 6 to 12 hours. The interval depends on the characteristics of the organism, its sensitivity to medication. Modafinil is effective in such diseases:

  • Delayed Sleep Phase Syndrome;
  • Multiple Sclerosis;
  • Parkinson’s Disease;
  • Depersonalization.

After the therapeutic course, many patients have noticed weight loss. Armodafinil is recommended in case of serious sleep disorders. Also, the drug protects the body from the negative effects of schizophrenia.

Comparison with Adrafinil


Adrafinil is designed to work on the central nervous system of the brain. It is legal in the United States and boasts the following benefits:

  • Nervous Systemmood booster;
  • stimulant;
  • the increases in energy levels;
  • positive effects and a good motivator;
  • an increase in Mental Alertness.

The following are the main differences between Armodafinil and Adrafinil:

AdrafinilArmodafinil
Adrafinil affects the catecholamine hormones and the adrenergic systemIt affects some parts of the brain to become alert
It immediately excites the person under stressUsed for people having irregular breath while sleeping
Provides the adrenaline rush by releasing EpinephrineShould not be used to make up for lack of sleep
It makes the brain suddenly alert to its surrounding environmentDecreases sleepiness during work
Sold as ProvigilSold as Nuvigil
Less potentHighly potent

What about Waklert?

Waklert is very similar to Armodafinil in composition and effects but is made in India. This drug is a modified version of Modafinil and is considered to be twice as strong. Only a small portion of Waklert is needed to reach its desired effects.

Is Caffeine Better Than Armodafinil?

Caffeine has many side effects, and an excess of caffeine can lead to the following health issues:

  • Сaffeineinsomnia;
  • nervousness;
  • restlessness;
  • irritability;
  • stomach upset;
  • fast heartbeat;
  • muscle tremors.

Some users prefer to take caffeine to help stay awake and keep focused, due to it being labeled as a naturally occurring stimulant found in trees and plants. Armodafinil is very similar effects to caffeine, although Armodafinil is more potent and effective than caffeine.

Its effects are immediately noticeable after ingesting and delivers a powerful feeling of wakefulness, comparable to a large dose of caffeine.

But unlike caffeine, Armodafinil does not cause the jitters, nervousness or anxiety, and does not contribute to an increase of blood pressure or pulse rate.

Other Drug Comparison

Artvigil also treats individuals with sleep disorders, and like Armodafinil, it is of a higher potency so you only have to take 150 mg of the drug, as compared to the 200 mg of Modafinil. The benefits of Artvigil are identical to that of Armodafinil, as well as the same side effects: headaches, nausea, dizziness and insomnia. It is not addictive or habit-forming, and its side effects are limited.

When treating ADHD in adults or narcolepsy, Adderall is an alternative to Armodafinil. Composition of Aderall includes a combination of amphetamine and dextroamphetamine. These components are powerful Central nervous system stimulants. Stimulants are changing the chemical composition of the brain and nerves. The change of structure may lead to hyperactivity, easy excitability and controlled impulsive behavior. There are more associated health risks that can occur if you take Adderall, especially if you suffer from glaucoma, overactive thyroid, severe agitation, moderate to severe high blood pressure, heart disease or coronary artery disease, or a history of drug or alcohol addiction.

Try them both! We offer free Modafinil samples & free Armodafinil samples!