Modalert: work, uses, benefits

Modalert: Benefits, Work and Uses

Modalert: Benefits, Work and Uses

Modalert is much less expensive than brand name drugs like Provigil. Modalert contains the same active ingredients found in Provigil but Provigil can cost as much as $50 per pill if you do not have insurance coverage.

Modalert is the generic name for Modafinil, which is a drug that induces a state of wakefulness. In fact, the names “Modalert” and “Modafinil” often get used interchangeably since they are made from exactly the same formula. Users take it for help with staying awake and to improve their focus. Increased focus and wakefulness improves their work.

Another benefit of Modalert is its ability to enhance cognition and to improve a person’s decision-making. Modalert works on brain chemicals that control sleep and wakefulness (the mechanism is similar to Armodafinil).

Modafinil has been around for a long time and was first approved as a treatment for sleep disorders in 1998. These days, some doctors prescribe it for a range of other conditions, such as depression and multiple sclerosis. According to some researchers, it is also an effective treatment for attention deficit hyperactivity disorder (ADHD). It is important to note that there is presently no evidence of its value as an ADHD treatment.

The US Food and Drug Administration (FDA) has approved Modafinil as a narcolepsy treatment. It is a Schedule IV substance and is sold under a variety of brand names. The Schedule IV classification denotes a drug with a relatively low likelihood of abuse.

Modalert: work, uses, benefits

How Does Modalert Work?

One of the things that allow Modafinil to be effective is its ability to cross the blood brain barrier. This is how it gets into the central nervous system. Once there, it acts on brain various brain chemicals including:


Modalert acts on the dopamine transporter to inhibit dopamine reuptake. Dopamine is the neurotransmitter responsible for pleasure, which is why some modafinil users say the drug makes them more motivated.


Modafinil also has an effect on the brain’s histamine levels so that the user is more wakeful during the day. Histamine is a monoamine hormone that plays a major role in the in the sleep-wake cycle, which means that it is important for daytime wakefulness. This wakefulness is the main benefit of Modalert.


Orexin is a neuropeptide that plays a role in the sleep-wake cycle. Animal studies indicate that defective orexin systems may be responsible for narcolepsy.


Serotonin is the neurotransmitter responsible for keeping moods balanced; a lack of serotonin results in depression.


Norepinephrine functions much like adrenaline in that it boosts wakefulness and increases attention.

Note that the exact mechanism behind the above effects is still unknown.

Along with its effects on the brain, studies have also found that Modalert has significant neuroprotective properties. Another benefit is that it is an effective antioxidant, with the ability to give neural cells a health boost.

Effects of Modalert Tablets

In 2015, scientists in the UK published an overview of the drug’s effect on people who were not sleep deprived. This was the first such overview in seven years. Their conclusion was that modafinil could be the first nootropic agent that was “well-validated.” This means that it is arguably the first real example of a smart drug that can aid with studying and similar activities.

The fact that histamine operates differently from amphetamine-based stimulants means that it can make users more wakeful and alert, without having much of an effect on their blood pressure.

One of the major effects of Modalert is its ability to aid in the formation and storage of memories. This effect is likely due to its stimulation of the glutamate receptors in the brain and the fact that it inhibits GABA neurotransmission. As a result, users of Modalert tend to perform better on tasks that involve memory and learning. GABA inhibition can also stop users feeling fatigued.

Modalert’s aforementioned antidepressant effects are probably due to its effects on the brain’s dopamine transport system. It inhibits the transport of dopamine, thus increasing concentrations of the pleasure-boosting neurotransmitter.

To a significant extent, Modalertโ€™s effects are the opposite of those that come with cocaine withdrawal. As a result, it is being considered as a possible treatment for cocaine addiction.

Effects of Modalert Shown in Studies
Condition Research Results
ย Fatigue ย According to six studies, Modalert significantly reduces fatigue, especially in cases were an individual is sleep deprived.
ย Cognition ย Four studies show that using Modalert is consistently improved cognition for sleep deprived people.
ย Working Memory ย Five studies show that working memory is improved with Modalert usage.

Side Effects

Potential side effects for Modafinil include nausea, stomach pain and anxiety. In rare cases, some people may be allergic. Allergies may present with symptoms like mouth sores and hives. Users who encounter any of these symptoms should discontinue use immediately. It is worth noting that Modalert is still far safer than amphetamine-based stimulants.

Clinical and Recreational Uses of Modafinil

The approved clinical uses of modafinil include:

Treatment of Narcolepsy

One of the main characteristics of narcolepsy is excessive sleepiness in the daytime. In addition, there are other symptoms like cataplexy and sleep paralysis. A study of Modafinil showed that it had no effect on night-time sleepiness but it did improve daytime wakefulness.

Shift Work Sleep Disorder

This sleep disorder usually causes symptoms such as insomnia and excessive sleepiness in people who work at night or who have rotating shifts. It can affect their physical health, along with their ability to be productive and their safety. In one study, individuals who took modafinil performed better on the Psychomotor Vigilance Test.

Obstructive Sleep Apnea

People with this condition suffer from airway blockages during sleep. The result is disrupted sleep and fatigue during the daytime. A study of modafinil showed that within four weeks, subjects who were given the drug saw improvements over subjects given a placebo. Note that when used for treating obstructive sleep apnea, the user will still need to use a CPAP machine. They should not stop using the machine unless instructed by their physician.

Off-label and Recreational Uses of Modalert

Modalert is an effective cognitive enhancer; in fact, this is the main motive behind its off-label use. However, the drug is only approved for the treatment of sleep disorders. The fact that it is a Schedule IV controlled substance means that individuals in the US will not have the ability to purchase it from a pharmacy without a prescription.

Because many doctors refuse to prescribe a drug for off-label uses, those who want to use the drug to enhance cognition must order it from outside of the country. They can do this since pharmacies in other countries are not under the FDA’s governance.

While Modalert does affect the same areas of the brain as well-known addictive drugs like cocaine, it does not produce euphoria. The fact that it does not provide feelings of elation or exhilaration means that the potential for addiction is low.

What modafinil can do is stabilize mood. It makes thoughts more positive and provides the user with a boost to their confidence and their sense of well-being. As such, Modalert is effective for lessening the severity of anxiety and for helping to reduce stress.

Modafinil has been used to treat conditions such as:

Atypical Depression

This condition can cause symptoms like over-eating and hypersomnia.

Some users have found that Modafinil helps them to use weight as it causes them to burn more calories. In addition, it has the ability to reduce appetite. Users can reduce their calorie intake by almost 40% per day.

Alzheimer’s Disease

Alzheimer’s disease can severely impede a person’s cognition. Modafinil is considered a potential treatment for the cognitive deficits caused by the disease.

How to Take Modalert

When using Modalert, the first question that you should consider is how much to take. In other words, what is the right dosage? Choosing the right dosage is important for maximizing the benefits and minimizing side effects. Modalert comes in two dosages: 100mg and 200mg. Of the two, the 200mg option is easier to find.

The most widely recommended dose is 200mg taken once a day, but you can start with a lower dose and increase it until you find what works for you. The best time of day to take it is in the morning, as taking it at midday or in the afternoon could lead to problems with sleep at night. To see the effects in less time, take it on an empty stomach. It will still be effective if taken on a full stomach, but it will take longer to start working.

If the standard dose of 200mg is not working, note that users can take up to 400mg with few negative effects; however, it is not clear whether a higher dose provides additional benefits. It is best to seek the advice of a medical professional if you are not sure which dose would suit your needs.

Benefits of Modalert

Treatment for Sleep Disorders

For individuals with sleep disorders, Modalert can be very beneficial in that it improves their cognitive abilities while they are sleep deprived. Users benefit from added clarity and improved focus. This is especially the case for those with narcolepsy.

Mood Improvement

Users typically have an elevated mood possibly due to Modalert’s effect on dopamine systems.


A common question from people considering Modalert is this: how long does it last? Modalert can provide a user with up 10 to 12 hours of wakefulness, which is why users should take it in the morning as opposed to later in the day.


Modalert makes tasks more enjoyable. The increase in the enjoyment of tasks is likely due to the increased dopaminergic activity.


The enhanced focus that users get from Modalert helps them to get more done. As many of the benefits are related to fully awake, students often use Modalert when studying for important exams. It is effective enough that many people are concerned that it can give some students an unfair advantage.

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